Thursday, March 18, 2010

danger hypothesis ---- transplantation [graft ]

Acordng to matzinger's danger pathway [model ] the cause of transplant rejection has been xplained as this

"Foreign entities that are not associated with

microbes include transplants and fetuses. Why

should the former be rejected and the latter not?

Although the INS model would suggest that

neither should be rejected because they are not

associated with microbial stimulators, and the

old SNS models would suggest that both should

be rejected because they are nonself, the Danger

model suggests that healthy fetuses should

not be rejected because they do not send alarm

signals. Transplants, however, cannot be performed

without surgical and/or ischemic damage.

Thus, to induce the acceptance of transplants

without lifelong immunosuppression, we

should mimic the body’s own way of inducing

tolerance, i.e., by blocking the endogenous

alarm and/or costimulatory signals"

My query

In a breast reconstructn surgey in a lady using muscle flap from her own latissimus dorsi muscle

Or

inCABG , VEIN graft in a patient from his own long sapphenous vein

Surgical damage occurs but no immune rejection does occur. Why so ?

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