Acordng to matzinger's danger pathway [model ] the cause of transplant rejection has been xplained as this
"Foreign entities that are not associated with
microbes include transplants and fetuses. Why
should the former be rejected and the latter not?
Although the INS model would suggest that
neither should be rejected because they are not
associated with microbial stimulators, and the
old SNS models would suggest that both should
be rejected because they are nonself, the Danger
model suggests that healthy fetuses should
not be rejected because they do not send alarm
signals. Transplants, however, cannot be performed
without surgical and/or ischemic damage.
Thus, to induce the acceptance of transplants
without lifelong immunosuppression, we
should mimic the body’s own way of inducing
tolerance, i.e., by blocking the endogenous
alarm and/or costimulatory signals"
My query
In a breast reconstructn surgey in a lady using muscle flap from her own latissimus dorsi muscle
Or
inCABG , VEIN graft in a patient from his own long sapphenous vein
Surgical damage occurs but no immune rejection does occur. Why so ?
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