EVEN WHEN IMMUNE SYSTEM IS HEALTHY THEN ALSO MALIGNANT CELL MAY ESCAPE LYSIS BECOZ

EVEN WHEN IMMUNE SYSTEM IS HEALTHY THEN ALSO MALIGNANT CELL MAY ESCAPE LYSIS BECOZ

1. CERTAIN CANCER CELLS MAY STOP EXPRESSING THE SURFACE ANTIGEN{IMMUNO MODULATION }

2. SOME NEOPLASTIC CELLS FORM A MUCO PROTEIN THAT BINDS TO SURFACE OF TUMOR CELL AND MASKS{HIDES} THE TUMOR ANTIGEN........THESE MUCOPROTEINS{SIALO MUCIN} ARE NORMAL BODY PROTEIN AND EVOKE NO IMMUNITY

3. CERTAIN TUMOR CELLS INVOKE IMMUNE SYSTEM TO PRODUCE BLOCKING ANTIBODY THAT CANNOT ACTIVATE COMPLEMENT SYSTEM{=NO CELL LYSIS}

4. SOME TUMOR PRODUCE IMMUNO SUPPRESSIV CYTOKINE EXAMPL- TGF beta THAT SUPRESS CELL--MEDIATED-IMUNITY
IT IS PROVED THAT ALFA FETO PROTEIN IS ALSO AN IMMUNO SUPRESSANT

5. THE RATE OF CANCER CELL DESTRUCTION MAY BE EXCEEDED BY RATE OF THEIR DIVISION

6. DURING METASTASIS VIA VEINS, THE CELLS ARE ATTACKED BY IMMUNE CELLS BUT 1 IN 1000 TUMOR CELLS ESCAPE WBC-DESTRUCTION DUE TO THE REASON OF BEING COATED WITH FIBRINOGEN